Table 1.

A comparison of the indices of renal handling of creatinine, PAH and sinistrin between the study arms (F, M, F + M). Creatinine clearance measured from plasma and urine creatinine concentrations and estimated using the Cockcroft and Gault equation is given. The urinary recovery (Ae), clearance (CL) and renal clearance (CL_R) of sinistrin and PAH, as well as the net renal secretion (CLsecr) of PAH, are also given (mean ± s.d.; (range)).

Parameter	Fluconazole (F) study arm	Markers@ (M) study arm	Markers@ + Fluconazole (F + M) study arm	P value* (95% CI of difference)
CLcr measured	145 ± 26	136 ± 21	138 ± 23	0.672†
(ml min−1)	(103–178)	(101–163)	(98–174)
CLcr estimated	142 ± 22	146 ± 32	144 ± 26	0.939†
(ml min−1)	(115–180)	(104–216)	(116–186)
CLcrsecr		17 ± 25	8 ± 33	0.473
(ml min−1)		(−33–45)	(−40–50)	(−15,–33)
Sinistrin CL		139 ± 44	143 ± 45	0.482
(ml min−1)		(82–234)	(81–227)	(−16,–7)
Sinistrin Ae		2286 ± 335	2447 ± 213	0.116
(mg)		(1509–2645)	(2122–2760)	(−347,–24)
Sinistrin CLR		119 ± 31	130 ± 40	0.317
(ml min−1)		(80–187)	(76–207)	(−31,–9.6)
PAH CL		697 ± 183	663 ± 166	0.398
(ml min−1)		(449–1021)	(483–1061)	(−42,–111)
PAH Ae		1379 ± 124	1459 ± 141	0.069
(µmol)		(1210–1630)	(1190–1685)	(−158,−2)
PAH CLR		469 ± 145	467 ± 146	0.945
(ml min−1)		(284–713)	(337–855)	(−107,–111)
Net PAH CLsecr		370 ± 130	359 ± 134	0.631
(ml min−1)		(187–583)	(252–729)	(−41,–63)

^*Paired t-test: Markers (M) vs Markers + Fluconazole (F + M) a. 95% confidence interval of differences.

^*anova: Fluconazole (F) vs Markers (M) vs Markers + Fluconazole (F + M) @Markers were sinistrin, PAH and pindolol.