Table 3.
Pharmacokinetic parameters (mean ± s.d.; (range)) describing fluconazole disposition and renal handling when administered alone and concomitantly with the markers in 12 healthy subjects.
| Parameter | Fluconazole (F) study arm | Markers + Fluconazole (F + M) study arm | P value* (95% CI of difference) |
|---|---|---|---|
| Cmax (mg l−1) | 1.96 ± 0.44 | 1.92 ± 0.34 | 0.634 |
| (1.15–2.48) | (1.55–2.53) | (−0.11–0.19) | |
| tmax (h) | 2.1 ± 1.6 | 2.3 ± 1.3 | 0.578 |
| (0.5–6.0) | (0.7–4.0) | (−0.80–0.44) | |
| Ae (mg) | 70 ± 14 | 67 ± 14 | 0.524 |
| (41–91) | (50–88) | (−6–12) | |
| fu | 0.842 ± 0.024 | 0.822 ± 0.024 | 0.005 |
| (0.787–0.871) | (0.775–0.860) | (0.01–0.03) | |
| CL/F (ml min−1) | 21.4 ± 4.3 | 20.3 ± 3.7 | 0.117 |
| (14.3–31.0) | (12.5–25.5) | (−0.2–2.4) | |
| CLR (ml min−1) | 14.9 ± 3.8 | 13.6 ± 3.4 | 0.159 |
| (10.7–22.2) | (9.0–17.7) | (−0.4–2.9) | |
| CLNR (ml min−1) | 6.5 ± 4.3 | 6.7 ± 3.5 | 0.874 |
| (1.9–18.2) | (2.3–12.8) | (−2.3–2.0) | |
| CLuR (ml min−1) | 17.7 ± 4.5 | 16.6 ± 4.3 | 0.278 |
| (12.5–26.0) | (10.7–22.8) | (−0.8–3.1) | |
| Clfilt (ml min−1) | 106 ± 31 | ||
| (64–161) | |||
| Clreabs (ml min−1) | 93 ± 29 | ||
| (55–142) |
*
Paired t-test: Fluconazole (F) vs Markers + Fluconazole (F + M) study arms.