Table 3.
Summary of parameter estimates for the final model including patient covariate effects.
| Parameter* | Mean value | Inter-individual variability s.d.** | CV** | Difference¶ mean, [95% CI] |
|---|---|---|---|---|
| CL/F (groups A, B) (l h−1) | 256 | |||
| 98 | 47 | 138, [+ 70, + 206] | ||
| CL/F (group C) (l h−1) | 118 | |||
| V1/F (groups A, B) (l) | 1320 | |||
| 336 | 31 | 668, [+ 314, + 1022] | ||
| V1/F (group C) (l) | 652 | |||
| Q (l h−1) | 200 | 314 | 166 | – |
| V2/F (l) | 1127 | 39 | 32 | – |
| ka (h−1) | 0.46 | 0.28 | 74 | – |
| Residual variability (ng ml−1) | 82 | 34 | – |
*
CL/F, oral clearance; V1/F, central volume of distribution; Q, intercompartmental clearance; V2/F, peripheral volume of distribution; ka, absorption rate constant.
**
Represent values for the whole population.
¶
Mean difference (95% confidence interval (C.I.)) between group A/B and C for CL/F and V1/F.