Table 1.
Characteristics of the 193 patients studied. Mean (s.d.).
| Characteristics | Index |
|---|---|
| Number of patients | 193 |
| Female (%) | 47.4 |
| Male (%) | 52.6 |
| Syrup (%) | 62.3 |
| Tablets (%) | 37.7 |
| Number of observations | 302 |
| CBZ dosage (mg kg−1 day−1) | |
| Mean | 16.71 (8.38) |
| Maximum | 66.67 |
| Minimum | 4.23 |
| CBZ concentration (mg l−1) | |
| Mean | 7.81 (3.34) |
| Maximum | 20.5 |
| Minimum | 1.0 |
| Weight (kg) | |
| Mean | 34.90 (20.52) |
| Maximum | 84.5 |
| Minimum | 4.84 |
| Age (years) | |
| Mean | 12.48 (10.08) |
| Medium | 10 |
| Maximum | 51 |
| Minimum | 0.3 |
| Percentage of patients on (%) | |
| Monotherapy | 52.3 |
| Polytherapy | 47.7 |
| Phenytoin | 12.2 |
| Phenobarbitone | 26.5 |
| Phenytoin and phenobarbitone | 2.3 |
| Race (%) | |
| Chinese | 74.3 |
| Indian | 5.3 |
| Malay | 11.5 |
| Others | 8.9 |
| CBZ L/D ratio | |
| Mean | 0.56 (0.30) |
| Maximum | 1.79 |
| Minimum | 0.06 |
| Correlation coefficientγ | 0.816 |
| Apparent clearance (l day−1 kg−1)* | |
| Mean | 2.50 (1.94) |
| Maximum | 16.76 |
| Minimum | 0.56 |
s.d. = standard deviation; CBZ = carbamazepine; L/D = level/dose.
γ
Correlation between age and weight.
*
Reciprocal of CBZ L/D ratio.