Table 2.
Comparison of monotherapy and polytherapy. Mean (s.d.).
| Characteristics | Monotherapy | Polytherapy |
|---|---|---|
| Number of patients | 101 | 92 |
| Number of observations | 157 | 145 |
| Female (%) | 49 | 45.5 |
| Male (%) | 51 | 54.5 |
| CBZ dosage (mg kg−1 day−1) | ||
| Mean | 15.30 (6.60) | 17.89 (9.72)* |
| Maximum | 36.95 | 66.67 |
| Minimum | 4.23 | 4.96 |
| CBZ concentration (mg l−1) | ||
| Mean | 8.21 (3.38) | 7.38 (3.26)* |
| Maximum | 20.5 | 20 |
| Minimum | 1 | 1 |
| Weight (kg) | ||
| Mean | 29.77 (18.20) | 40.72 (21.33)* |
| Maximum | 84 | 84.5 |
| Minimum | 4.84 | 8 |
| Age (years) | ||
| Mean | 9.74 (7.78) | 15.45 (11.40)* |
| Medium | 8 | 12 |
| Maximum | 47 | 51 |
| Minimum | 0.3 | 0.5 |
| CBZ L/D ratio | ||
| Mean | 0.63 (0.33) | 0.48 (0.23)* |
| Maximum | 1.79 | 1.18 |
| Minimum | 0.06 | 0.07 |
| Correlation coefficient γ | 0.8411 | 0.7831 |
| Apparent CL (l day−1 kg−1) ** | ||
| Mean | 2.16 (1.65) | 2.86 (2.17)* |
| Maximum | 16.76 | 15.38 |
| Minimum | 0.56 | 0.85 |
s.d. = standard deviation; CBZ = carbamazepine; L/D = level/dose; CL = clearance.
*
Significantly different from monotherapy.
γ
Correlation between age and weight.
**
Reciprocal of CBZ L/D ratio.