Table 4.

Model development in the NONMEM analysis step.

Models	Change in −2LL	P value
1.CL = f(A,W,PB)
2. CL = f(A,W,PB,PH)	−0.015	NS
3. CL = f(A,W,R,PB,PH)	−0.093	NS
4. CL = f(A,W,G,R,FM,PB,PH)	−0.324	NS
5. CL = f(A,W,G,R,FM,PB,PH,PN)	−0.434	NS
6. CL = f(A,W)	36.03	1.94 × 10−9*
7. CL = f(W,PB)	35.93	2.05 × 10−9*
8. CL = f(A,PB)	130.45	2.63 × 10−30*
Basic structural CL model	191.15	2.50 × 10−42*

A = age; W = weight; G = gender; R = race; FM = formulation; PB = presence of phenobarbitone

PH = presence of phenytoin; PN = presence of nonanticonvulsants

−2LL = minus twice the log likelihood

NS = not significant.

^*Significant.