Table 5.
Parameters | Meaning | Estimated values | s.e. |
---|---|---|---|
θ1 | Coefficient for combination of A, W and PB | 40.7 | 14.4 |
θ2 | Power for A | 0.494 | 0.133 |
θ3 | Power for W | −1.17 | 0.168 |
θ4 | Proportionality constant for PB | 1.44 | 0.159 |
σCL2 | Inter-patient variance | 0.046 | 0.029 |
σε2 | Intra-patient variance | 0.033 | 0.012 |
A = age; W = body weight; PB = presence of phenobarbitone; s.e. = standard error.