Table 1.

Median (upper and lower quartile) values of pharmacokinetic parameters for DHC and DHM

CL/F (l h−1)	V/F (l)	ka (h−1)	tlag (h)	kel (h−1)	fm(DHM)systemic	fm(DHM)1st pass	k(DHM)	V(DHM)
43	203	11	0.3	0.216	0.015	0.022	0.339	200
(34–46)	(177–224)	(9–39)	(0.250–0.467)	(0.173–0.258)	(0.010–0.019)	(0.010–0.046)	(0.303–0.648)	Fixed

See the appendix for definition of abbreviations used in Table 1.