Table 1.

Overall estimate of the incidence of ADRs in paediatric in/out-patients.

Setting/Source, y	Incidence of ADRs	95% CI
ADRs in hospitalized children
McKenzie et al. [17]	10.64	8.28,12.99
Whyte et al. [18]	6.0	4.43,7.65
Mitchell et al. [19]	16.78	14.98-18.57
Choonara et al. [20]	5.60	2.84–8.35
Vasquez De La Villa et al. [21]	4.35	2.72,5.99
Gill et al. [22]	7.01	5.34,8.68
Gonzales-Martin et al. [23]	13.70	9.14,18.25
Turner et al. [24]	11.08	9.18,12.98
Martinez-Mir et al. [25]	11.52	8.76,14.29
Meta-analytic weighted average	9.53	6.81,12.26
ADRs leading to paediatric hospital admission
McKenzie et al. [26]	2.02	1.56,2.48
Yosselson-Superstine et al. [27]	3.20	2.05,4.35
Mitchell et al. [28]	2.00	1.66,2.34
Martinez-Mir et al. [29]	4.10	2.38,5.82
Easton et al. [30]	0.59	0.22,0.96
Meta-analytic weighted average	2.09	1.02,3.77
ADRs in outpatient children
Sanz et al. [31]	0.75	0.29,1.22
Cirko-Begovic et al. [32]	2.74	2.08,3.41
Menniti-Ippolito et al. [33]	1.51	1.24,1.78
Meta-analytic weighted average	1.46	0.70,3.03