Table 2.
Summary of prospective studies on ADRs in hospitalized children.
| Setting/year [ref.] | Population studied | Prescription level (mean) | ADRs occurrence |
|---|---|---|---|
| Paediatric teaching hospital | 70 children (10.6%) experienced ADRs | ||
| Gainesville (USA) | 658 children | 4.2 drugs per child | ADRs probability/severity not reported |
| 1973 [17] | Age not reported | ||
| Paediatric teaching hospital | 51 children (6.0%) experienced ADRs | ||
| Glasgow (UK) | 844 children | 2.3 drugs per child | 119 ADRs were reported: |
| 1977 [18] | Age not reported | 106 (89%) definite/probable24 (20%) severe | |
| Paediatric teaching hospital | |||
| Boston (USA) | 1669 children | 7.6 drugs per child | 280 children (16.8%) experienced ADRs |
| 1979 [19] | Mean age: 6.8 years | ADR probability/severity not reported | |
| Paediatric teaching hospital | 15 children (5.6%) experienced ADRs | ||
| Liverpool (UK) | 268 children | 1.5 drugs per child | 17 ADRs were reported |
| 1984 [20] | Age not reported | 17 (100%) definite/probable Severity not reported | |
| Teaching hospital | 26 children (4.4%) experienced ADRs | ||
| Granada (Spain) | 597 children | 3.8 drugs per child | 28 ADRs were reported: |
| 1989 [21] | Mean age: 3.8 years | 19 (68%) definite/probable | |
| Age range:1–8 years | 3 (11%) severe | ||
| Paediatric teaching hospital | 63 children (7%) experienced ADRs | ||
| Liverpool (UK) | 899 children | 76 ADRs were reported: | |
| 1995 [22] | Age range: 0–16 years | Not reported | 40 (53%) definite/probable8 (11%) severe |
| Teaching hospital | 30 children (13.7%) experienced ADRs | ||
| Santiago (Chile) | 219 children | 4.3 drugs per child | 46 ADRs were reported: |
| 1998 [23] | Mean age: 3.8years | 30 (65%) definite/probable | |
| Age range: 0–15 years | 8 (17%) severe | ||
| Paediatric teaching hospital | 116 children (11.1%) experienced ADRs | ||
| Liverpool (UK) | 3 months | 4.3 drugs per child | 157 ADRs were reported: |
| 1999 [24] | 89 (57%) definite/probable | ||
| 1047 children | 17 (11%) severe | ||
| Mean age: 1 year | |||
| Paediatric teaching hospital | 512 children | 59 children (11.5%) experienced ADRs | |
| Valencia (Spain) | Median age:8.5 months | 2.6 drugs per child | 68 ADRs were reported: |
| 1999 [25] | Age range:1–24 months | 53 (78%) definite/probable5 (7%) severe | |