Table 4.

Concentration-dependent effects of cimetidine, enoxacine and imipramine on CMV423 metabolism by human liver microsomes following co-incubation. The results are expressed as a percentage of controls (vehicles only). Each value represents the mean % change calculated from duplicate experiments. Coefficients of variation were below 15%.

Drug	Concentration (µm)	Effect on RPR 127025 formation (%)	Effect on RPR 123830 formation (%)
Cimetidine	3	0.0	+ 2
	10	−6.0	+ 10
	30	−6.0	+ 19
	100	−12.0	+ 5
	300	−16.0	−20
Enoxacine	3	−4.0	+ 7
	10	−5.0	0
	30	−12.0	+ 1
	100	−24.0	−25
	300	−36.0	−31
Imipramine	0.3	+ 3.0	−1
	1	−2.0	−6
	3	−7.0	−7
	10	+ 2.0	−7
	30	−12.0	−10
	100	−25.0	−29