Table 5.
Time-dependent effects of cimetidine, enoxacine, ethinyl estradiol, imipramine and methadone on CMV423 metabolism by human liver microsomes. The results are expressed as percentage of controls (vehicles only). Each value represents the mean of a triplicate assay. Coefficients of variation were below 15%.
| Drug (µm) | Pre-incubation time (min) | Effect on RPR 127025 formation (%) | Effect on RPR 123830 formation (%) |
|---|---|---|---|
| Cimetidine | 0 | +4 | −15 |
| (10) | 10 | −6 | +16 |
| 20 | +1 | −6 | |
| 30 | −3 | −13 | |
| Enoxacine | 0 | −5 | −9 |
| (20) | 10 | −23 | −4 |
| 20 | +2 | +2 | |
| 30 | −1 | −1 | |
| Ethinyloestradiol | 0 | +11 | +11 |
| (1) | 10 | +5 | +23 |
| 20 | +9 | +4 | |
| 30 | +2 | −9 | |
| Imipramine | 0 | +7 | +7 |
| (1) | 10 | −1 | +8 |
| 20 | −1 | −4 | |
| 30 | −4 | −5 | |
| Methadone | 0 | −4 | not analysed |
| (10) | 10 | −1 | not analysed |
| 20 | −8 | not analysed | |
| 30 | 11 | not analysed |