Table 2.
Rizatriptan pharmacokinetic parameters (arithmetic means±s.d.) (n = 12) | |||||
---|---|---|---|---|---|
Parameter | 10 mg rizatriptan+ placebo propranolol | 10 mg Rizatriptan+ 60 mg propranolol | 10 mg rizatriptan 1 h after 60 mg propranolol | 10 mg rizatriptan 1 h after 120 mg propranolol | 10 mg rizatriptan 2 h after 120 mg propranolol |
AUC(0,∞) (ng ml−1 h) | 61.8 ± 12.1 | 80.9 ± 16.6 | 84.7 ± 27.8 | 89.3 ± 21.9 | 86.3 ± 22.9 |
Geometric mean AUC ratio | 1.38* | 1.42* | 1.53* | 1.45* | |
vs rizatriptan alone | (1.24, 1.54) | (1.27, 1.58) | (1.37, 1.71) | (1.30, 1.61) | |
(97.5% confidence interval) | |||||
Cmax (ng ml−1) | 19.5 ± 4.8 | 25.0 ± 4.8 | 27.1 ± 9.9 | 24.8 ± 7.9 | 27.2 ± 10.1 |
Geometric mean Cmax ratio vs | 1.39* | 1.48* | 1.29* | 1.45* | |
rizatriptan alone | (1.21, 1.60) | (1.29, 1.70) | (1.12, 1.49) | (1.26, 1.67) | |
(90% confidence interval) | |||||
tmax (h) | 0.9 ± 0.5 | 0.8 ± 0.4 | 1.2 ± 0.4 | 1.2 ± 0.7 | 1.3 ± 0.7 |
Kela | 0.379 | 0.361 | 0.379 | 0.363 | 0.337 |
(0.335, 0.423) | (0.317, 0.405) | (0.335, 0.423) | (0.319, 0.407) | (0.293, 0.381) | |
t½ (h)b | 1.9 | 2.0 | 1.7 | 2.0 | 1.9 |
Ue (%) | 9.7 ± 3.0 | 11.5 ± 3.2 | 11.0 ± 4.0 | 14.8 ± 4.8 | 10.6 ± 3.3 |
CLR (ml min−1) | 261.5 ± 64.6 | 242.8 ± 72.8 | 227.4 ± 85.9 | 294.3 ± 119.4 | 229.9 ± 134.8 |
P < 0.01 vs 10 mg rizatriptan+propranolol placebo.
Arithmetic mean (95% confidence interval).
Harmonic mean.
AUC(0,∞)=area under the concentration-time curve from 0 to infinity; Cmax=maximal plasma concentration; tmax=time to achieve maximal plasma concentration; Kel=elimination rate constant; CLR=renal clearance.