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Perindoprilat brachial vascular resistance (BVR) decrease concentration-effect relationship in healthy volunteers (HV, solid line) and in congestive heart failure (CHF, dotted line) patients. The models have the following parameters: Emax=−41%, CE50 = 4.95 ng ml−1, γ= 2.25, and E0 = 0 in HV, and Emax=−60%, CE50 = 1.38 ng ml−1, γ= 3.06, and E0 = 0 in CHF patients.
