Table 4.
Pharmacodynamic parameters of the relationship between perindoprilat concentrations and effects on pulmonary capillary wedge pressure in congestive heart failure patients.
| Subject number | Emax (mmHg) | Asymptotic s.d. Emax (mmHg) | CE50 (ng ml−1) | Asymptotic s.d. CE50 (ng ml−1) | γ | ke0 (h−1) | r2 |
|---|---|---|---|---|---|---|---|
| 2 | −12 | 0.25 | 1.84 | 0.07 | 3.00 | 0.11 | 0.9855 |
| 3 | −19 | 0.34 | 0.28 | 0.03 | 2.00 | 0.16 | 0.9711 |
| 4 | −10 | 0.83 | 0.77 | 0.09 | 4.00 | 0.10 | 0.8380 |
| 5 | −8 | 0.40 | 0.21 | 0.03 | 4.00 | 0.07 | 0.7742 |
| 6 | −10 | 1.27 | 3.82 | 0.61 | 5.00 | 0.08 | 0.8124 |
| 7 | −11 | 0.78 | 0.16 | 0.07 | 5.00 | 0.20 | 0.6239 |
| 8 | −15 | 2.63 | 3.68 | 1.63 | 1.00 | 0.06 | 0.8030 |
| 10 | −4 | 0.54 | 1.56 | 0.20 | 5.00 | 0.09 | 0.5492 |
| Mean±s.d. | −11 ± 4 | 1.54 ± 1.50 | 3.63 ± 1.51 | 0.11 ± 0.05 |
Emax: maximum theoretical effect, CE50: concentration of perindoprilat which induces an effect of 50% of Emax, γ: Hill coefficient, ke0: first order rate constant which governs the kinetics of the drug in the effect compartment, r2: determination coefficient. Baseline value of the variable of effect (E0) equal to 24 ± 3 mmHg.