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Dose-response curve of noradrenaline (NA) alone (▪) and in the presence of the ETA-selective antagonist BQ-123 (NA + BQ-123, •) and the ETB-selective antagonist BQ-788 (NA + BQ 788, ▴) in the human microcirculation. ⋆⋆ P < 0.01 vs NA; NS not significant. ΔAUC: Area under the curve of the time-response to each constrictor. PU: perfusion units.
