Table 2.
Details of patients classified by whether or not they were taking metformin when studied. Data are mean ± s.d. or geometric mean and (s.d. range).
| Not taking metformin | Taking metformin | P value | |
|---|---|---|---|
| Number | 91 | 181 | – |
| Age (years) | 66.7 ± 8.8 | 66.2 ± 9.3 | 0.67 |
| Sex (% males) | 60.4 | 54.1 | 0.31 |
| Diabetes duration (years) | 7.6 ± 4.3 | 10.8 ± 6.2 | < 0.001 |
| Daily metformin dose (g) | – | 1.5[1.0–2.0]¶ | – |
| Body mass index (kg m−2) | 28.5 ± 4.5 | 30.1 ± 4.9 | 0.006 |
| Resting pulse rate (beats min−1) | 66 ± 13 | 71 ± 12 | 0.003 |
| Supine systolic blood pressure (mmHg) | 145 ± 23 | 148 ± 24 | 0.42 |
| Supine diastolic blood pressure (mmHg) | 72 ± 10 | 74 ± 11 | 0.09 |
| Fasting plasma glucose (mmol l−1) | 8.0 (6.1–10.4) | 8.9 (7.0–11.5) | < 0.001 |
| HbA1c (%) | 6.8 (5.8–8.0) | 7.6 (6.5–8.8) | < 0.001 |
| Fasting plasma lactate (mmol l−1) | 1.58 (1.09–2.30) | 1.86 (1.34–2.59) | < 0.001 |
| Serum creatinine (µmol l−1) | 94 ± 19 | 100 ± 58 | 0.33 |
| Serum bicarbonate (mmol l−1) | 26.8 ± 2.4 | 26.1 ± 2.4 | 0.032 |
| Serum potassium (mmol l−1) | 4.4 ± 0.3 | 4.6 ± 0.4 | < 0.001 |
| Ischaemic heart disease (%) | 30.9 | 26.5 | 0.48 |
| β-adrenoceptor blockers (%) | 13.8 | 11.6 | 0.70 |
| Angiotensin converting enzyme inhibitors (%) | 16.0 | 30.7 | 0.009 |
| Non-steroidal anti-inflammatory drugs (%) | 6.4 | 2.8 | 0.19 |
¶
Median and [interquartile range].