Table 2.

Predicted DMXAA–anticancer drug interactions in vivo.

Anti-cancer drugs	Apparent Ki value (µm)	Metabolic pathway of inhibition	[I] (µm)	Predicted R (%)	Rc (%)
Daunorubicin	131	Hydroxylation	0.01–1.001	0	0
DACA	0.59	Hydroxylation	0.21–18.52	0.1–6.4	0.1–6.6
Vinblastine	319	Glucuronidation	0.01–0.173	0	0
Vincristine	350	Glucuronidation	0.01–0.083	0	0
Amsacrine	230	Glucuronidation	0.71–3.704	0	0

¹Paul et al. [28]; Galettis et al. [29]. Approximately 63% of daunorubicin binds to human plasma [30].

²Kestell et al. [14]. Approximately 97% of DACA binds to human plasma [14].

³Nelson et al. [31]. Approximately 75% of vinblastine and vincristine binds to human plasma proteins [32].

⁴Petros et al. [33]. Approximately 97% amsacrine binds to human plasma [34].