Table 1.
Furazolidone pharmacokinetic parameters in serum after a single oral (200 mg) dose of furazolidone in 18 healthy volunteers during [OME(+)] and without [OME(−)] pretreatment with omprazole.
| Pharmacokinetic parameters (geometric mean) | OME (−) | OME (+) | OME (+)/OME (−) ratios (expressed as %) | P value |
|---|---|---|---|---|
| AUC(0,24 h) (µg ml−1 h) | 0.89 | 0.73 | 82 | 0.150 |
| (CI 95%) | (0.67, 1.10) | (0.43, 1.03) | (64.20, 93.64) | |
| AUC(0,∞) (µg ml−1 h) | 0.90 | 0.74 | 82 | 0.133 |
| (CI 95%) | (0.68, 1.11) | (0.44, 1.04) | (64.71, 93.69) | |
| Cmax (µg ml−1) | 0.34 | 0.24 | 70.6 | 0.023⋆ |
| (CI 95%) | (0.25, 0.43) | (0.15, 0.34) | (41.2, 110.9) | |
| Ke (h−1) | 0.21 | 0.36 | 171 | 0.164 |
| (CI 95%) | (0.15, 0.27) | (0.22, 0.50) | (40.7, 185.2) | |
| t½ (h) | 4.87 | 3.90 | 80 | 0.077 |
| (CI 95%) | (2.63, 7.11) | (2.10, 5.71) | (48.68, 131.6) | |
| tmax (h) | 2.5 | 2.4 | 98 | 0.946 |
| (CI 95%) | (1.85, 3.04) | (2.06, 2.71) | (77.23, 129.4) | |
| Clearance (µg ml−1) | 0.28 | 0.32 | 114 | 0.66 |
| (CI 95%) | (0.18, 0.39) | (0.19, 0.45) | (94.74, 115.4) |