Figure 1.

Cutaneous blood flow (± 95% confidence intervals) in heated skin, expressed as a percentage of flow at reference sites that did not receive drug administration. Blood flow after the acute administration of saline did not differ between the saline pretreated and control sites (open squares, n = 19). However, blood flow was greater at the site of saline pretreatment than at reference sites (95% confidence interval > 0). The response to noradrenaline is presented for subjects who met the criterion for adrenergic vasoconstriction after the acute administration of noradrenaline (filled squares, n = 15, except for the site of saline pretreatment where n = 7). Blood flow was greater at pretreated sites than at the site of acute administration of noradrenaline (*P < 0.001).