Table 2.

Summary of the pharmacokinetic parameters for saquinavir obtained on day 14 with the different SQV-SGC regimens.

Parameter		A 800 mg SQV-SGC	C 400:400 mg ritonavir:SQV-SGC	D 300:600 mg ritonavir:SQV-SGC	E 200:800 mg ritonavir:SQV-SGC	F 300:800 mg ritonavir:SQV-SGC	G 400:800 mg ritonavir:SQV-SGC	H 400:600 mg ritonavir:SQV-SGC
Cmax(0,24 h) (µg ml−1)	Geometric mean	0.53	2.92	3.94	4.52	5.78	5.06	4.78
	Range	0.20–3.99	1.78–4.72	2.36–9.63	2.80–7.25	3.33–8.44	2.62–6.75	3.16–7.65
AUC(0,24 h) (µg ml−1 h)	Geometric mean	3.03	30.92	41.93	52.17	65.21	67.72	58.93
	Range	1.31–18.74	14.68–70.07	25.01–154.43	29.56–105.22	40.07–89.64	32.81–93.44	42.36–115.56
Cmin(0,24 h) (µg ml−1)	Geometric mean	0.04	0.84	0.74	0.79	1.16	1.48	1.41
	Range	0.02–0.12	0.32–1.71	0.22–2.70	0.43–2.68	0.50–1.66	0.65–2.88	0.86–4.32
t1/2 (h)	Harmonic mean	9.6	6.0	6.4	5.4	4.8	5.4	5.5
	Geometric mean	9.7	6.0	6.6	5.5	4.9	5.5	5.5
	Range	7.6–12.6	5.1–7.8	4.8–10.2	4.9–8.7	4.2–6.3	4.1–7.5	4.6–7.3