Table 3.
Summary of the pharmacokinetic parameters for ritonavir obtained on day 14 with the different ritonavir regimens.
| Parameter | B 400 mg ritonavir | C 400:400 mg ritonavir:SQV-SGC | D 300:600 mg ritonavir:SQV-SGC | E 200:800 mg ritonavir:SQV-SGC | F 300:800 mg ritonavir:SQV-SGC | G 400:800 mg ritonavir:SQV-SGC | H 400:600 mg ritonavir:SQV-SGC | |
|---|---|---|---|---|---|---|---|---|
| Cmax (0−24) (µg ml−1) | Geometric mean | 7.95 | 7.73 | 5.75 | 3.32 | 5.42 | 6.51 | 7.16 |
| Range | 4.83–18.74 | 6.72–9.26 | 4.58–6.55 | 2.52–4.15 | 4.34–7.66 | 3.91–9.88 | 3.40–10.19 | |
| AUC(0,24 h) (µg ml−1 h) | Geometric mean | 79.36 | 76.65 | 53.30 | 35.11 | 58.30 | 73.63 | 73.31 |
| Range | 39.54–171.36 | 48.93–100.68 | 32.45–90.11 | 21.96–51.47 | 50.68–65.06 | 50.27–126.20 | 33.29–117.33 | |
| Cmin(0,24 h) (µg ml−1) | Geometric mean | 2.35 | 2.83 | 1.63 | 0.87 | 1.49 | 2.08 | 2.39 |
| Range | 1.13–3.32 | 2.02–4.98 | 0.98–2.90 | 0.38–1.57 | 1.12–1.87 | 1.47–3.69 | 1.25–3.49 | |
| t½ (h) | Harmonic mean | 5.3 | 5.0 | 4.3 | 4.1 | 3.5 | 3.3 | 4.1 |
| Geometric mean | 5.4 | 5.1 | 4.5 | 4.3 | 3.6 | 3.4 | 4.2 | |
| Range | 3.3–7.1 | 4.0–6.4 | 2.5–7.1 | 2.8–9.8 | 2.8–5.7 | 2.2–5.3 | 2.9–7.1 |