Table 4.
Intersubject variability in terms of the saquinavir pharmacokinetics for all dosing regimens tested. Data are presented as percentage coefficient of variation.
Coefficient of variation % | |||
---|---|---|---|
Regimen | Drug treatment (mg; RTV:SQV-SGC) | Saquinavir AUC(0,24 h) | Saquinavir Cmax(0,24 h) |
A | 800 (SQV-SGC alone) | 105 | 124 |
C | 400:400 | 63 | 39 |
D | 300:600 | 68 | 49 |
E | 200:800 | 46 | 32 |
F | 300:800 | 32 | 30 |
G | 400 800 | 36 | 32 |
H | 400 600 | 33 | 33 |