Table 3.
Parameter values for population model number 1.
| Parameter | Meaning | Value (CV%)* |
|---|---|---|
| Structural parameters | ||
| θ1 | Clearance (l h−1) | 3.20 (2.7) |
| θ2 | Volume of distribution (l) | 1820 (1.7) |
| θ3 | First-order absorption rate constant (h−1) | 0.694 (12.8) |
| Derived parameters | ||
| t½ | Elimination half-life (days) | 16.4 |
| tabs | Absorption half-life (h) | 1.0 |
| tmax | Time to reach peak concentration (h) | 8.6 |
| Variance parameters | ||
| ωCL/F | Intersubject variability in CL/F | 25.3† (14.0) |
| ωV/F | Intersubject variability in V/F | 14.8† (21.1) |
| covV/F, CL/F | Covariance between CL/F and V/F | 0.0265 (21.5) |
| ωKa | Intersubject variability in Ka | 61.2† (167) |
| σ | Residual variability | 17.9† (8.60) |
*
Imprecision of estimation (CV%=asymptotic standard error) parameter value. 100%).
†
Variability expressed as the coefficient of variation (CV%).