Table 2.

Absolute maternal and infant doses, average milk concentration, M/P_AUC, and relative infant dose for R- and S-methadone.

Subject	Daily maternal	M/PAUC		Average milk methadone concentration (μg l−1)		Daily infant dose (µg kg−1)		Relative infant dose (%)
	dose (mg kg−1)	R	S	R	S	R	S	R	S
Immature milk
1	1.44	0.44	0.24	144	115	21.6	17.3	3.0	2.4
2	1.56	0.22	0.12	42	26	6.3	3.9	0.8	0.5
3	1.66	0.58	0.35	113	89	17.0	13.4	2.0	1.6
4	0.9	0.78	0.39	146	69	21.9	10.4	4.8	2.3
5	0.75	0.90	0.48	121	74	18.2	11.1	4.8	2.9
6	1.2	0.96	0.55	259	126	38.9	18.9	6.5	3.2
7	2.14	0.86	0.55	181	87	27.2	13.1	2.5	1.2
8	1.4	0.71	0.39	185	121	27.8	18.2	3.9	2.6
Mean		0.68	0.38					3.54	2.09
s.d.		0.25	0.15					1.83	0.91
95% CI		0.5, 0.9	0.3, 0.5					2.0, 5.0	1.3, 2.8
Mature milk
1	1.44	0.54	0.30	89	76	13.4	11.4	1.9	1.6
2	1.56	0.39	0.24	135	119	20.3	17.9	2.5	2.2