Table 1.
Characteristics of the children in the Model Development and Model Validation Data Sets.
| Model development | Validation | Significance | |
|---|---|---|---|
| Total number of children | 57 | 26 | |
| Total number of courses | 83 | 39 | |
| Total number of observations | 581 | 226 | |
| Number of concentration observations per patient | |||
| Mean±s.d. (range) | 6.9 ± 3.8 | 6.2 ± 2.6 | NS1 |
| (1–19) | (1–11) | ||
| Method of AmB administration | |||
| Number in dextrose/number in lipid | 43/40 | 14/25 | NS2 |
| Age (months) | 74.5 | 96.5 | |
| Median (range) | (9–190.5) | (12–219) | NS1 |
| Weight (kg) | |||
| Mean±s.d. | 21.6 ± 10.2 | 25.2 ± 12.1 | NS1 |
| Height (cm) | |||
| Mean±s.d. | 113.8 ± 24.7 | 122.2 ± 27.7 | NS1 |
| Gender | |||
| Number of males/number of females | 49/34 | 26/13 | NS2 |
| Number of children with the following diagnoses: | |||
| ALL | 22 | 13 | |
| AML | 13 | 5 | |
| Neuroblastoma | 13 | 1 | |
| Rhabdomyosarcoma | 16 | 2 | |
| Ewings sarcoma | 0 | 3 | |
| Osteosarcoma | 1 | 1 | |
| Synovial sarcoma | 0 | 2 | |
| Wilm's tumour | 2 | 2 | |
| Non Hodgkins lymphoma | 6 | 1 | |
| Germ cell tumours | 4 | 2 | |
| Aplastic anaemia | 0 | 1 | |
| Other | 6 | 6 | |
| Number of courses after BMT | |||
| Yes/No/unknown | 31/52/0 | 10/25/2 | NS2 |
| Number of courses where TPN was | |||
| administered | |||
| Yes/No/unknown | 52/31/0 | 18/18/1 | NS2 |
ALL=acute lymphoblastic leukaemia, AML=acute myeloid leukaemia, BMT=bone marrow transplant, TPN=total parenteral nutrition.
1
Significance assessed using the Mann–Whitney-U-test.
2
Significance assessed using the chi square test.