Table 2.

Population pharmacokinetic parameters of AmB.

	Basic Model			Covariate Model
Parameter	Mean	% CV	95% CI	Mean	% CV	95% CI
CL l h−1)	0.86	35	0.77, 0.95	0.88	19	0.83, 0.93
V (l)	8.73	53	7.31, 10.15	9.97	49	8.47, 11.47
k12 (h−1)	0.26	57	0.21, 0.31	0.27	55	0.22, 0.32
k21 (h−1)	0.14	61	0.11, 0.17	0.16	48	0.14, 0.18
Sigma (mg l−1)	0.027			0.027
ML	6.99			−11.3
AIC	0.0017			0.0333

% CV=intersubject variability expressed as percent coefficient of variation.

95% CI=lower and upper limits of the 95% confidence interval.

Sigma=residual error.

ML=Maximum Likelihood.

AIC=Akaike Information Criterion.