Table 5.
Comparison of the posterior Bayesian estimates of the pharmacokinetic parameters (mean ± s.d.) of AmB administered in dextrose and AmB administered in lipid emulsion.
| Parameter | Dextrose (n = 57) | Lipid (n = 65) | Significance1 |
|---|---|---|---|
| Weight (kg) | 23.3 ± 11.3 | 21.4 ± 10.5 | NS |
| CL (l h–1) | 0.79 ± 0.23 | 0.96 ± 0.24 | P < 0.005 |
| CL (l h–1kg–1) | 0.038 ± 0.015 | 0.052 ± 0.021 | P < 0.0005 |
| V (l) | 8.51 ± 3.26 | 9.72 ± 4.24 | NS |
| V (l kg–1) | 0.41 ± 0.20 | 0.58 ± 0.43 | P < 0.05 |
| Vss (l kg–1) | 1.18 ± 0.57 | 1.74 ± 1.35 | P < 0.05 |
| t1/2 λ1 (h) | 1.46 ± 0.33 | 1.45 ± 0.26 | NS |
| t1/2 λz (h) | 26.4 ± 11.6 | 26.1 ± 12.8 | NS |
| k12 (h–1) | 0.28 ± 0.13 | 0.28 ± 0.14 | NS |
| k21 (h–1) | 0.15 ± 0.05 | 0.14 ± 0.03 | NS |
| MRT (h) | 33.0 ± 15.5 | 32.4 ± 17.8 | NS |
s.d.=standard deviation.
1
The pharmacokinetics of AmB infused in dextrose and lipid emulsion were compared using the Mann–Whitney-U-test.