Table 2.

Cisapride metabolism by transfected cells expressing CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP3A4, CYPA3A5, CYP3A7 and controls. Results are expressed as nmol metabolites formed in 24 h and are the mean±s.e. mean for four determinations, except for CYP3A4 and CYP3A7 (six determinations).

		Metabolites (nmol formed in 24 h)
Transfected cells	M1	M2	M5	M7
Ad293	N.D.	N.D.	N.D.	N.D.
CYP1A1	N.D.	N.D.	N.D.	N.D.
CYP1A2	N.D.	N.D.	N.D.	N.D.
CYP2C8	N.D.	N.D.	N.D.	N.D.
CYP2C9	N.D.	N.D.	N.D.	N.D.
CYP3A4	0.77 ± 0.5	0.025 ± 0.02	0.02 ± 0.03	0.02 ± 0.03
CYP3A5	N.D.	N.D.	N.D.	N.D.
CYP3A7	0.01 ± 0.03	N.D.	N.D.	N.D.

N.D. not detectable (< 0.005 nmol 24 h⁻¹).