Table 3.
CYP3A content and activity from foetal, neonate and adult livers (values are the mean of duplicate determinations).
| Metabolite formation (nmol min−1 mg−1 protein) cisapride | ||||||||
|---|---|---|---|---|---|---|---|---|
| Immunoreactive CYP3A (unit mg−1 protein) | Test 6OH (CYP3A4) | DHEA 16α (CYP3A7) | M1 | M2 | M5 | M7 | Total | |
| Fœtus 1 | 1.38 | N.D. | 0.823 | 0.11 | 0 | 0 | 0 | 0.11 |
| Fœtus 2 | 1.07 | 0.002 | 1.12 | 0 | 0 | 0 | 0 | 0 |
| Fœtus 3 | 0.51 | N.D. | 0.039 | 0.06 | 0 | 0 | 0 | 0.06 |
| Fœtus 4 | 1.32 | 0.004 | 0.176 | 0.25 | 0.01 | 0 | 0 | 0.26 |
| Neonate 1 | 0.06 | 0.005 | 0.32 | 0 | 0 | 0 | 0 | 0 |
| Neonate 2 | 0.19 | 0.007 | 0.411 | 0 | 0 | 0 | 0 | 0 |
| Neonate 3 | 0.92 | 0.045 | 2.77 | 0.68 | 0.01 | 0 | 0 | 0.69 |
| Neonate 4 | 0.93 | 0.029 | 2.93 | 40.14 | 1.30 | 5.43 | 3.62 | 50.49 |
| Neonate 5 | 0.63 | N.D. | 0.225 | 0.40 | 0.01 | 0.04 | 0 | 0.45 |
| Neonate 6 | 0.57 | N.D. | 0.035 | 0.04 | 0 | 0.03 | 0 | 0.07 |
| Neonate 7 | 1.12 | 0.096 | 0.716 | 1.62 | 0.05 | 0.17 | 0.14 | 1.98 |
| Neonate 8 | 2.1 | N.D. | 0.643 | 9.24 | 0.46 | 1.38 | 0.51 | 11.59 |
| Neonate 9 | 1.57 | 0.105 | 0.274 | 1.76 | 0.06 | 0.22 | 0.16 | 2.2 |
| Adult 1 | 1.1 | 0.102 | 0.088 | 1.55 | 0.09 | 0.23 | 0.2 | 2.07 |
| Adult 2 | N.D. | N.D. | N.D. | 0.52 | 0.05 | 0.06 | 0.04 | 0.67 |
N.D. not determined.