Table 1.
Allele (a) and genotype (b) frequencies for CYP2C9 in the Italian and Ethiopian populations.
| a | |||||
|---|---|---|---|---|---|
| Variant allele | Frequency in Italian volunteers (n = 157) | Frequency of Ethiopian volunteers (n = 150) | Absolute difference | 95% CI on the difference | P** |
| CYP2C9*1 | 0.796 | 0.751–0.841 | 0.933 | 0.905, 0.961 | NS |
| CYP2C9*2 | 0.112 | 0.077–0.147 | 0.043 | 0.020, 0.066 | < 0.01 |
| CYP2C9*3 | 0.092 | 0.060–0.124 | 0.023 | 0.006, 0.040 | < 0.001 |
| b | |||||
|---|---|---|---|---|---|
| Genotype | Number of subjects | Observed (Predicted)* frequency (%) | Number of subjects | Observed (Predicted)* frequency (%) | |
| CYP2C9*1/*1 | 102 | 65.0 (65.0) | 130 | 86.7 (87.0) | |
| CYP2C9*1/*2 | 24 | 15.3 (16.8) | 13 | 8.7 (8.1) | |
| CYP2C9*1/3 | 22 | 14.0 (14.5) | 7 | 4.6 (4.3) | |
| CYP2C9*2/*2 | 4 | 2.5 (1.1) | 0 | 0 (0.2) | |
| CYP2C9*3/*3 | 2 | 1.3 (0.8) | 0 | 0 (0.05) | |
| CYP2C9*2/*3 | 3 | 1.9 (2.0) | 0 | 0 (0.2) | |
*
Predicted frequencies calculated according to the Hardy–Weinberg equation.
**
P difference between Italians and Ethiopians. CI confidence interval.