Table 1.
Pharmacokinetic (PK) parameters (mean±s.d.) of (−)-cisapride and (+)-cisapride after a single oral dose of 10 mg rac-cisapride (CIS) in water (control) treated healthy volunteers (n = 10).
| PK parameters | (−)-CIS | (+)-CIS | Ratio [(−)-/(+)-CIS] | Mean differences (95% CI) | P value |
|---|---|---|---|---|---|
| tmax (h) | 1.35 ± 0.4 | 1.75 ± 0.5 | 0.8 ± 0.22 | −0.4 (−0.78, −0.03) | 0.037 |
| Cmax (ng ml−1) | 30 ± 13.6 | 10.5 ± 3.4 | 2.98 ± 1.27 | 19.6 (10.6, 28.6) | 0.0008 |
| AUC(0, ∞) (ng ml−1 h) | 201.2 ± 161 | 70 ± 51.5 | 3.7 ± 3.7 | 131 (17, 245) | 0.029 |
| t1/2 (h) | 4.7 ± 2.7 | 4.8 ± 3.1 | 1.22 ± 0.82 | −0.07 (−2.6, 2.5) | 0.95 |
Peak plasma concentration (Cmax), time to Cmax (tmax), area under the plasma concentration-time curve (AUC(0, ∞)) and elimination half-life (t½).