Table 1.

Effects of CYP2C polymorphisms on clinical consequences of drugs.

Enzyme	Drug	Interaction
CYP2C9	Warfarin	Prolonged bleeding time, increased incidence of severe bleeding episodes in PMs [61]
	Glipizide, tolbutamide	Possibility of low blood sugar levels in PMs [54]
	Phenyoin	Signs of overdose: ataxia, disturbances of consciousness, mental confusion [55]
CYP2C19	Diazepam	Unacceptable prolonged sedation in PMs, unconsciousness noted more frequently in Asian populations [29]
	Omeprazole	Reports of decreases in cure rates at low dosage in homozygous or heterozygous EMs [31]