Figure 3.

Individual oral clearance (CL/F) values for dihydroartemisinin on days 1 and 5 (a, n = 10) and for artemisinin on days −5, 1 and 5 (b, n = 10) when 500 mg artemisinin was given orally once daily on day −5 and from day 1 through day 5 with single oral administrations of 100 mg artesunate on days 1 and 5 in healthy male Vietnamese subjects (Group AM). Values above horizontal lines represent the geometric average and its 95% confidence interval of the interindividual ratios of oral clearance values between study days (CL/F_{day 1}/CL/F_{day −5} and CL/F_{day 5}/CL/F_{day 1}), and vertical arrows depict occasions of drug administration.