Table 1.

Study design with repeated administration of artesunate (Group AS, n = 10) or with repeated administration of artemisinin (Group AM, n = 10).

	Day −14	Day −5	Day1	Day2	Day3	Day4	Day5
Physical examination	X						X
Sampling for pharmacokinetics		X	X				X
Group AS
AS (100 mg orally daily)		X	X	X	X	X	X
AM (500 mg orally daily)			X				X
Group AM
AS (100 mg orally daily)			X				X
AM (500 mg orally daily)		X	X	X	X	X	X