Table 3.
Dihydroartemisinin pharmacokinetic parameters determined on days −5, 1 and 5 in Group AS (n = 10, artesunate was given on day −5 and from day 1 through day 5, artemisinin was given on days 1 and 5) and in Group AM (n = 10, artemisinin was given on day −5 and from day 1 through day 5, artesunate was given on days 1 and 5). Values of parameters are shown as geometric mean (95% CI).
| Dihydroartemisinin parameters | Day −5 | Day 1 | Day 5 |
|---|---|---|---|
| Group AS | |||
| AUC(0, t) (nmol l−1 h) | 2289***† | 6776 | 6065 |
| (1567, 3343) | (4664, 9844) | (4412, 8339) | |
| AUC(0, ∞) (nmol l−1 h) | 2765***† | 8121 | 6910 |
| (1637, 4670) | (5534, 11917) | (5098, 9365) | |
| CL/F (l h−1) | 94***† | 32 | 38 |
| (56, 159) | (22, 47) | (28, 51) | |
| t½ (h) | 0.55***† | 1.63 | 1.33 |
| (0.44, 0.70) | (1.34, 1.99) | (1.12, 1.57) | |
| Cmax (nmol l−1) | 1664** | 2821 | 2620 |
| (999, 2772) | (1968, 4043) | (1793, 3827) | |
| Group AM | |||
| AUC(0, t) (nmol l−1 h) | 5061 | 3120** | |
| (3465, 7391) | (2001, 4864) | ||
| AUC(0, ∞) (nmol l−1 h) | 5907 | 3579** | |
| (4226, 8255) | (2370, 5404) | ||
| CL/F (l h−1) | 39 | 64** | |
| (34, 46) | (48, 85) | ||
| t½ (h) | 1.42 | 1.02*** | |
| (1.26, 1.60) | (0.85, 1.24) | ||
| Cmax (nmol l−1) | 2505 | 1970* | |
| (1973, 3179) | (1526, 2543) | ||
†
n = 7
*
P < 0.05
**
P < 0.01
***
P < 0.001; (compared with the values on day 1).