Table 4.

Artemisinin pharmacokinetic parameters determined on days −5, 1 and 5 in Group AS (n = 10, artesunate was given on day −5 and from day 1 through day 5, artemisinin was given on days 1 and 5) and in Group AM (n = 10, artemisinin was given on day −5 and from day 1 through day 5, artesunate was given on days 1 and 5). Values of parameters are shown as geometric mean (95% CI).

Artemisinin parameters	Day −5	Day 1	Day 5
Group AS
AUC(0, t) (nmol l−1 h)		8339	5219**
		(7153, 9720)	(4028, 6761)
AUC(0, ∞) (nmol l−1 h)		9056	5638**
		(7652, 10719)	(4320, 7358)
CL/F (l h−1)		196	315**
		(165, 232)	(241, 410)
t½ (h)		2.48	2.50
		(2.05, 3.01)	(1.99, 3.13)
Cmax (nmol l−1)		2794	2047*
		(2353, 3317)	(1546, 2710)
Group AM
AUC(0, t) (nmol l−1 h)	7733***	5081	1572***
	(5674, 10539)	(4320, 5975)	(1051, 2350)
AUC(0, ∞) (nmol l−1 h)	8555**	5763	1807***
	(6212, 11781)	(4813, 6901)	(1249, 2614)
CL/F (l h−1)	207**	308	981***
	(151, 285)	(257, 368)	(678, 1420)
t½ (h)	2.21	2.97	2.53
	(1.72, 2.84)	(2.27, 3.88)	(1.99, 3.23)
Cmax (nmol l−1)	2408**	1803	629***
	(1824, 3179)	(1413, 2299)	(414, 956)

^*P < 0.05

^**P < 0.01

^***P < 0.001; (compared with the values on day 1).