Table 2.
Parameters of the pharmacokinetic model of ibuprofen plasma concentration vs time profiles, obtained in an naïve pooled data fit of the data from the 12 study participants (see also Figure 1).
| Population central values (and % SEE) | ||
|---|---|---|
| Parameter | R-ibuprofen | S-ibuprofen |
| CL (l h−1) | 4.9 (3.5%) | 4.64 (4.9%) |
| Q (l h−1) | 2.8 (21.7%) | 4.1 (18.7%) |
| V central (l) | 5.1 (4.4%) | 5.45 (4.7%) |
| V peripheral (l) | 4.1 (9.7%) | 5.2 (7.7%) |
| ka (h−1) | 1.52 (12.1%) | |
| tlag (h) | ‘Test’: 0.1 (29.9%), ‘Reference’: 0 Residual error | |
| σ2 | 12.9 | |
The inversion clearance of R- to S-ibuprofen was set to 0.6 times the total clearance of R-ibuprofen [23]. % SEE: percent standard error of the parameter estimate, calculated as 100 times the ratio of the standard error of estimate (SEE) to the estimated parameter.