Table 2.
Population estimates of etoposide pharmacokinetics in 50 patients with solid tumours.
| Mean | CV (%) | Covariables | Mean with covariables | Residual CV (%) | Significant covariables | |
|---|---|---|---|---|---|---|
| CL (l h−1) | 1.14 | 25 | CLCR, bili | 1.14 | 17 | CLCR |
| V (l) | 6.0 | 25 | %PB, BSA | 6.1 | 15 | BSA, PB |
| k12 (h−1) | 0.14 | 21 | %PB, BSA | 0.14 | 13 | PB |
| k21 (h−1) | 0.06 | 29 | CLCR | 0.07 | 20 | CLCR |
| F | 0.44 | 22 | – | 0.44 | 22 | – |
CL: systemic clearance; V: volume of distribution of the central compartment; k12 and k21 are the transfer rate constants from one compartment to the other; F: oral bioavailability; CLCR: creatinine clearance; bili: bilirubin; %PB: % of protein binding; BSA: body surface area; CV%: coefficient of variation %.