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Correlation between haematological toxicity (% decrease ANC from baseline to nadir value) and clinical or PK parameters.
| Covariable/parameter | Correlation coefficient | P value |
|---|---|---|
| Creatinine clearance | 0.39 | 0.01 |
| Dose/m2 of etoposide | 0.45 | 0.0025 |
| C24 | 0.30 | 0.05 |
| Clearance | 0.36 | 0.02 |
| Unbound AUCp.o. | 0.50 | 0.0007 |
| Unbound AUCi.v. | 0.54 | 0.0003 |
