Figure 4.

Increases in PPF ratio are strongly associated with striatal LTD. (A) Effect of 10 μM nifedipine on LTD induction and PPF ratio (n = 6). (B) Effect of 10 mM EGTA applied in the intracellular solution on LTD induction and PPF ratio (n = 5). (C and D, Upper) Paired EPSCs taken at the indicated times before and after either HFS or depolarization (Depol) alone, respectively. (Lower) PPF ratio plotted against time before and after HFS alone (C, n = 5) or depolarization (D, n = 8). Waveforms in C and D are averages of 20 individual paired EPSCs. Points in A–D are values averaged over 1-min time epochs.