Table 1.
Mean AUCi.n./AUCi.v.ratios (expressed as percentage) at various times after the administration of 4 and 7 mg diazepam to seven healthy subjects.
AUCi.n./AUCi.v. (%) Time (min) | |||||||||
---|---|---|---|---|---|---|---|---|---|
I.n.dose | 3 | 5 | 8 | 11 | 15 | 20 | 30 | 45 | 60 |
4 mg | 12a | 14 | 17 | 21 | 25 | 29 | 34 | 40 | 45 |
7 mg | 7a | 8 | 12 | 15 | 19 | 22 | 27 | 34 | 42 |
P valueb | 0.07 | 0.05 | 0.09 | 0.14 | 0.17 | 0.12 | 0.09 | 0.19 | 0.63 |
One AUC value was left out because it was thought to be an outlier, being more than three times the standard deviation above all the other values.
P values from the comparison between the two doses.