Table 4.

Mean (± s.d., n = 7) EEG amplitude (nV) values of differences in the β-frequency range (16–35 Hz) at the vertex electrode between before and after drug administration.

Formulation	Difference between before and after administration	95% confidencea intervals
Placebo	64 ± 163	[−57, 184]
4 mg i.n.	189 ± 232*	[17, 360]
7 mg i.n.	139 ± 68*	[89, 189]
5 mg i.v.	222 ± 120*	[133, 342]

^aP < 0.05

^*P < 0.01

^**P < 0.001

^***vs placebo.

^bNo significant differences were found between formulations or subjects.