Table 3.
Comparison of plasma 1-OH MDZ/MDZ concentration ratios within and between studies.
| Comparison Test/Reference | Geometric LS mean test | Geometric LS mean reference | Ratio | 95% CI | P value |
|---|---|---|---|---|---|
| 6-DC study 2/6-DC study 1 | 4.60 | 4.59 | 1.00 | (0.76, 1.33) | 0.985 |
| 5-DC study 2/MDZ alone study 1 | 7.64 | 7.79 | 0.98 | (0.74, 1.30) | 0.891 |
| MDZ alone study 1/6-DC study 1< | 7.79 | 4.59 | 1.70 | (1.36, 2.11) | < 0.001 |
| 5-DC study 2/6-DC study 2 | 7.64 | 4.60 | 1.66 | (1.34, 2.06) | < 0.001 |
5-DC five drug cocktail, excludes chlorzoxazone.
6-DC six drug cocktail, includes chlorzoxazone.