Table 5.
Plasma cortisol (AUC(0,24 h)) suppression vs baseline after repeated dose inhalations (1000 µg twice daily) of budesonide via Turbuhaler and of fluticasone via pMDI and Diskus.
| Regimen | Subjects | n | Plasma cortisol suppression (%) |
|---|---|---|---|
| Budesonide | Healthy | 13 | 54 (39, 66) |
| Turbuhaler | With asthma | 8 | 59 (34, 74) |
| Total | 21 | 56 (46, 65) | |
| Fluticasone pMDI | Healthy | 13 | 88 (84, 91) |
| Fluticasone Diskus | Healthy | 13 | 61 (48, 70) |
| With asthma | 8 | 68 (50, 80) | |
| Total | 21 | 64 (55,71) |
Values are given as geometric means (95% CI).