Table 1.

Derived kinetic constants for MPAG formation by human liver, kidney and jejunum microsomes^a.

Mean apparent	Km [µm]	Mean Vmax [nmol (min mg)−1]	Mean microsomal CLint [µl (min mg)−1]
Liverb	351	14.2	46.6
	(183–445)	(7.4–22.8)	(16.7–98.4)
Kidneyc	555d	41.1d	73.5
	(525–598)	(31.3–54.5)	(57.9–91.1)
Jejunumc	256	4.9	24.5
	(147–337)	(3.4–7.3)	(11.9–47.6)

^aMean data with range of values in parenthesis

^bn = 5

^cn = 3

^dP < 0.05 compared with liver and jejunum.