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a) The coloured areas show that the BP of [14C]-doxepin after ebastine 10 mg treatment were significantly higher than those after (+)-chlorpheniramine 2 mg treatment (P < 0.05, uncorrected) using SPM96. This means that those areas show the higher H1-receptor occupation of (+)-chlorpheniramine than that of ebastine. In contrast, (b) there is no area showing that the BP after (+)-chlorpheniramine treatment was higher those after ebastine treatment.
