Figure 6.

Effect of medetomidine (100 nM) on DMPP-evoked overflow of noradrenaline (a) and adrenaline (b) from the adrenal medulla of wild-type (WT) and knockout (KO) mice for each of the three α₂-adrenoceptor subtypes (α_2A, α_2B and α_2C). Medetomidine was added 15 min before DMPP 500 μM. Results are presented as percentage inhibition. Columns and vertical lines represent mean±s.e.m. (n=5). ^*Significantly different from corresponding values for the effect of medetomidine in WT; P<0.05. ^#Significantly different from corresponding values for the effect of medetomidine in α_2A and α_2B KO mice P<0.05.