Table 2.

Absolute and relative tissue levels (in pmol/mg tissue) of L-DOPA and DA, NA and AD in the adrenals from WT and KO mice for each of the three α₂-adrenoceptor subtypes (α_2A, α_2B and α_2C)

	WT	α2AKO	α2BKO	α2CKO
L-DOPA	5±2	5±1	3±1	16±3*
DA	191±56	198±67	200±94	177±51
NA	5921±866	5372±698	5678±1055	6274±529
AD	15113±2887	15107±2321	14678±2195	15322±1278
DA/L-DOPA	42±3	42±18	54±10	11±2*
NA/DA	33±5	29±3	26±5	34±4
AD/NA	2.9±0.6	3.0±0.7	2.5±0.5	2.6±0.3

Abbreviations: AD, adrenaline; DA, dopamine; DMPP, 1,1-dimethyl-4-phenylpiperazinium; KO, knockout; L-DOPA, L-3,4-dihydroxyphenylalanine; NA, noradrenaline; WT, wild type.

Values are presented as mean±s.e.m. (n=5–6). Significantly different from corresponding values in WT (^*P<0.05).