Table 2.
WT | α2AKO | α2BKO | α2CKO | |
---|---|---|---|---|
L-DOPA | 5±2 | 5±1 | 3±1 | 16±3* |
DA | 191±56 | 198±67 | 200±94 | 177±51 |
NA | 5921±866 | 5372±698 | 5678±1055 | 6274±529 |
AD | 15113±2887 | 15107±2321 | 14678±2195 | 15322±1278 |
DA/L-DOPA | 42±3 | 42±18 | 54±10 | 11±2* |
NA/DA | 33±5 | 29±3 | 26±5 | 34±4 |
AD/NA | 2.9±0.6 | 3.0±0.7 | 2.5±0.5 | 2.6±0.3 |
Abbreviations: AD, adrenaline; DA, dopamine; DMPP, 1,1-dimethyl-4-phenylpiperazinium; KO, knockout; L-DOPA, L-3,4-dihydroxyphenylalanine; NA, noradrenaline; WT, wild type.
Values are presented as mean±s.e.m. (n=5–6). Significantly different from corresponding values in WT (*P<0.05).