Table 3.
Tension induced by 10 μM ACh or 10 μM CCh in the presence or absence of epithelium, L-NAME, indomethacin, actinomycin and flutamide
| Contractile agent | Tension g mm−2 | |||||
|---|---|---|---|---|---|---|
| Control | Epithelium denuded | (+) L-NAME | (+) Indomethacin | (+) Actinomycin | (+) Flutamide | |
| 10 μM ACh | 43.1±6.2 (n=18) | 35.8±6.3 (n=6) | 28.8±0.2 (n=8) | 33.5±5.5 (n=6) | 47.6±8.5 (n=5) | 33.4±6.9 (n=7) |
| 10 μM CCh | 61.3±4.3* (n=17) | 61.02±8.7 (n=9) | 67.8±14.5 (n=6) | 55.6±7.5 (n=5) | 77.4±2.3 (n=5) | 84.9±1.2 (n=5) |
Data are means±s.e.m. from five to 18 experiments.
Significant differences between strips contracted with 10 μM ACh or 10 μM CCh at P<0.05 (*), Mann–Whitney U unrelated samples test.